Is mindfulness-based stress reduction useful among women with fibromyalgia?
Date of publication of the randomized controlled trial: June 2015
Design
Randomized controlled trial (RCT).
Participants
91 adult women (mean age not reported) diagnosed with fibromyalgia.
Intervention
A weekly 2.5-hour mindfulness-based stress reduction (MBSR) session for 8 weeks.
Comparator
Comparison: MBSR versus wait-list.
Major Outcomes
Outcome 1: Stress perception measured by Perceived Stress Scale (PSS). Higher scores indicated higher level of stress;
Outcome 2: Pain measured by Visual Analog Scale (VAS). Higher scores indicated higher level of pain;
Outcome 3: Sleep quality measured by Stanford Sleep Questionnaire (SSQ). Higher scores indicated worse sleep quality.
Settings
This trial was performed in an outpatient setting.
Comparison    MBSR versus wait-list.
Main Results
MBSR significantly reduced the level of stress perception (p<0.001) and improved sleep quality (p=0.038) among female fibromyalgia patients. However, the effect of MBSR for pain reduction was not significant (p=0.068).
Comparison: MBSR versus wait-list among female fibromyalgia patients.
Outcomes No. of studies (Total number of participants) Mean score (SD)/ No. of participants Heterogeneity test (I2) MD (95% CI) p value Overall quality of evidence*
Intervention Comparator
1 1 (91) 19.2 (7.2)/ 51 22.5 (6.5)/ 40 Not applicable as there is only 1 study. Not reported <0.001 High
2 1 (91) 60.4 (26.4)/ 51 68.5 (23.5)/ 40 Not applicable as there is only 1 study. Not reported 0.068 Moderate
3 1 (91) 8.5 (3.3)/ 51 9.3 (3.1)/ 40 Not applicable as there is only 1 study. Not reported 0.038 High
Keys: SD = standard deviation; MD = mean difference; CI = confidence interval.
Comparison    MBSR versus wait-list.
Main Results
MBSR significantly reduced the level of stress perception (p<0.001) and improved sleep quality (p=0.038) among female fibromyalgia patients. However, the effect of MBSR for pain reduction was not significant (p=0.068).
Comparison: MBSR versus wait-list among female fibromyalgia patients.
Outcomes 1 2 3
No. of studies (Total number of participants) 1 (91) 1 (91) 1 (91)
Mean score (SD)/ No. of participants Intervention 19.2 (7.2)/ 51 60.4 (26.4)/ 51 8.5 (3.3)/ 51
Comparator 22.5 (6.5)/ 40 68.5 (23.5)/ 40 9.3 (3.1)/ 40
MD (95% CI) Not reported Not reported Not reported
p value <0.001 0.068 0.038
Overall quality of evidence* High Moderate High
Keys: SD = standard deviation; MD = mean difference; CI = confidence interval.
Conclusion
Benefits
Compared to wait-list control, MBSR is effective in reducing perceived stress level and improving sleep quality among female fibromyalgia patients. For Outcome 1 & 3, the the overall quality of evidence is high. Further research is unlikely to have an important impact on our confidence in this estimate of effect. For Outcome 2, the overall quality of evidence is moderate. Further research is fairly likely to have an important impact on our confidence in this estimate of effect.
Harms
No adverse events were reported.
Link to Original Article
https://www.ncbi.nlm.nih.gov/pubmed/25425224
The synopsis is based on the following article:
Cash E, Salmon P, Weissbecker I, Rebholz WN, Bayley-Veloso R, Zimmaro LA, et al. Mindfulness meditation alleviates fibromyalgia symptoms in women: results of a randomized clinical trial. Annals of Behavioral Medicine. 2015 Jun 1;49(3):319-30.


* Interpretation of quality assessment results:
• Very low: Further research is most likely to have an important impact on our confidence in this estimate of effect.
• Low: Further research is likely to have an important impact on our confidence in this estimate of effect.
• Moderate: Further research is fairly likely to have an important impact on our confidence in this estimate of effect.
• High: Further research is unlikely to have an important impact on our confidence in this estimate of effect.
• Very high: Further research is most unlikely to have an important impact on our confidence in this estimate of effect.

Details of assessment method can be found at Chung VC, Wu XY, Ziea ET, Ng BF, Wong SY, Wu JC. Assessing internal validity of clinical evidence on effectiveness of CHinese and integrative medicine: Proposed framework for a CHinese and Integrative Medicine Evidence RAting System (CHIMERAS). European Journal of Integrative Medicine. 2015 Aug 31;7(4):332-41.