Can yoga improve health related quality of life in patients with history of colorectal cancer?
Date of publication of the randomized controlled trial: July 2015
Design
Randomized controlled trial (RCT).
Participants
54 adult patients (mean age: 68.3 years, male %: 61.1%) who had been surgically treated for histologically confirmed non-metastatic colorectal cancer (stage I-III).
Intervention
A weekly 90 minutes traditional Hatha yoga program for 10 weeks.
Comparator
Comparison: Yoga program versus wait-list control.
Major Outcomes
Outcome 1: Quality of life measured by Functional Assessment of Cancer Therapy – Emotional well-being scale. Higher scores indicated better quality of life.
Settings
This trial was performed in an outpatient setting.
Comparison    Yoga program versus wait-list control
Main Results
Yoga program significantly improved quality of life in the aspect of emotional well-being among patients with a history of colorectal cancer (MD: 1.59, 95% CI: 0.27 to 2.90), when compared to wait-list.
Comparison: Yoga program versus wait-list in patients with history of colorectal cancer
Outcome No. of studies (Total no. of participants) Mean score (SD)/ No. of participants Heterogeneity test (I2) MD (95% CI) Overall quality of evidence*
Intervention Comparator
1 1 (54) 20.6 (2.4)/ 27 18.77 (3.06)/ 27 Not applicable as there is only 1 study. 1.59 (0.27 to 2.90) Moderate
Keys: SD: standard deviation; CI: confidence interval; MD: mean difference.
Comparison    Yoga program versus wait-list control
Main Results
Yoga program significantly improved quality of life in the aspect of emotional well-being among patients with a history of colorectal cancer (MD: 1.59, 95% CI: 0.27 to 2.90), when compared to wait-list.
Comparison: Yoga program versus wait-list in patients with history of colorectal cancer
Outcome 1
No. of studies (Total no. of participants) 1 (54)
Mean score (SD)/ No. of participants Intervention 20.6 (2.4)/ 27
Comparator 18.77 (3.06)/ 27
MD (95% CI) 1.59 (0.27 to 2.90)
Overall quality of evidence* Moderate
Keys: SD: standard deviation; CI: confidence interval; MD: mean difference.
Conclusion
Benefits
Compared to wait-list control, yoga program significantly improves quality of life in the aspect of emotional well-being among patients with history of colorectal cancer. For Outcome 1, the overall quality of evidence is moderate. Further research is fairly likely to have an important impact on our confidence in this estimate of effect.
Harms
7 patients reported minor adverse events including abdominal pain, muscle soreness, neck pain and minor vertigo. All patients recovered without treatment. One patient reported hip pain and recovered with the use of analgesic drugs.
Link to Original Article
https://www.ncbi.nlm.nih.gov/pubmed/24395196
The synopsis is based on the following article:
Cramer H, Pokhrel B, Fester C, Meier B, Gass F, Lauche R, et al. A randomized controlled bicenter trial of yoga for patients with colorectal cancer. Psycho‐Oncology. 2015 Jul 1.


* Interpretation of quality assessment results:
• Very low: Further research is most likely to have an important impact on our confidence in this estimate of effect.
• Low: Further research is likely to have an important impact on our confidence in this estimate of effect.
• Moderate: Further research is fairly likely to have an important impact on our confidence in this estimate of effect.
• High: Further research is unlikely to have an important impact on our confidence in this estimate of effect.
• Very high: Further research is most unlikely to have an important impact on our confidence in this estimate of effect.

Details of assessment method can be found at Chung VC, Wu XY, Ziea ET, Ng BF, Wong SY, Wu JC. Assessing internal validity of clinical evidence on effectiveness of CHinese and integrative medicine: Proposed framework for a CHinese and Integrative Medicine Evidence RAting System (CHIMERAS). European Journal of Integrative Medicine. 2015 Aug 31;7(4):332-41.