Can mindfulness-based therapy improve quality of life among patients with drug-resistant epilepsy?
Date of publication of the randomized controlled trial: September 2015
Design
Randomized control trial (RCT).
Participants
60 adult epileptic patients (mean age: 35.12 years, male %: 46.7%) who were diagnosed with antiepileptic drug (AED) resistant epilepsy without organic mental disorder, psychotic disorders, psychogenic nonepileptic seizures, learning disability or mental retardation.
Intervention
Mindfulness-based therapy in group format with 4 biweekly sessions each lasted for 2.5 hours.
Comparator
Comparison 1: Mindfulness-based therapy versus social support program.
Major Outcomes
Outcome 1: Change in total score of the Patient-Weighted Quality of Life in Epilepsy Inventory (QOLIE-31-P). Higher scores indicated better quality of life.
Settings
This trial was performed in an outpatient setting.
Comparison    Mindfulness-based therapy versus social support program.
Main Results
Both mindfulness-based therapy group and social support group had improved total QOLIE-31-P score, with 6.23 for mindfulness-based therapy group (95% CI: 4.22 to 10.40) and 3.3 for social support group (95% CI: 1.03 to 5.58). However, it is unknown that whether such difference is significant.
Comparison: Mindfulness-based therapy versus social support program
Outcomes No. of studies (Total number of participants) Change in score (95%Cl)/ No. of participants Heterogeneity test (I2) MD (95% CI) p value Overall quality of evidence*
Intervention Comparator
1 1 (60) 6.23 (4.22 to 10.40)/30 3.3 (1.03 to 5.58) /30 Not applicable as there is only 1 study. Not reported Not reported Low
Keys: MD = mean difference; CI = confidence interval.
Comparison    Mindfulness-based therapy versus social support program.
Main Results
Both mindfulness-based therapy group and social support group had improved total QOLIE-31-P score, with 6.23 for mindfulness-based therapy group (95% CI: 4.22 to 10.40) and 3.3 for social support group (95% CI: 1.03 to 5.58). However, it is unknown that whether such difference is significant.
Comparison: Mindfulness-based therapy versus social support program
Outcomes 1
No. of studies (Total number of participants) 1 (60)
Change in score (95%Cl)/ No. of participants Intervention 6.23 (4.22 to 10.40)/30
Comparator 3.3 (1.03 to 5.58) /30
MD (95% CI) Not reported
p value Not reported
Overall quality of evidence* Low
Keys: MD = mean difference; CI = confidence interval.
Conclusion
Benefits
Compared to social support, whether mindfulness-based therapy is more effective in improving quality of life among patients with drug-resistant epilepsy is unknown. For Outcome 1, the overall quality of evidence is low. Further research is likely to have an important impact on our confidence in this estimate of effect.
Harms
No adverse events were reported.
Link to Original Article
https://www.ncbi.nlm.nih.gov/pubmed/26333801
The synopsis is based on the following article:
Tang V, Poon WS, Kwan P. Mindfulness-based therapy for drug-resistant epilepsy An assessor-blinded randomized trial. Neurology. 2015 Sep 29;85(13):1100-7.


* Interpretation of quality assessment results:
• Very low: Further research is most likely to have an important impact on our confidence in this estimate of effect.
• Low: Further research is likely to have an important impact on our confidence in this estimate of effect.
• Moderate: Further research is fairly likely to have an important impact on our confidence in this estimate of effect.
• High: Further research is unlikely to have an important impact on our confidence in this estimate of effect.
• Very high: Further research is most unlikely to have an important impact on our confidence in this estimate of effect.

Details of assessment method can be found at Chung VC, Wu XY, Ziea ET, Ng BF, Wong SY, Wu JC. Assessing internal validity of clinical evidence on effectiveness of CHinese and integrative medicine: Proposed framework for a CHinese and Integrative Medicine Evidence RAting System (CHIMERAS). European Journal of Integrative Medicine. 2015 Aug 31;7(4):332-41.